反应详情

A solution of 10 g of methylmagnesium chloride in 100 ml of tetrahydrofuran was added at a temperature of from 25° C. to 30° C., and with the exclusion of air, to 17 g of 2,2-dimethyl-3-(3-methylphenyl)-propionaldehyde (according to Example 3). After 5 hours at 30° C., the reaction mixture was poured onto ice and acidified with hydrochloric acid. The phases were then separated and the organic phase was washed with 100 ml of water and 100 ml of sodium bicarbonate solution. Finally, drying was carried out with solid potassium carbonate. Fractional distillation yielded 15 g of end product at 0.12 mbar in a temperature range of from 79° C. to 82° C.

1. additionthe reaction mixture was poured onto ice
2. customThe phases were then separated
3. washthe organic phase was washed with 100 ml of water and 100 ml of sodium bicarbonate solution
4. customFinally, drying
5. distillationFractional distillation
6. customyielded 15 g of end product at 0.12 mbar in a temperature range of from 79° C. to 82° C.