Water → HCID 70443965, compound

HRID 985975Notes

Reaction equation

HRID 985975 reaction equation
[ClH:1].O[CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5].O.[CH2:15]([NH2:33])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>C(O)(C)C>[ClH:1].[CH2:15]([NH:33][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

Participants

5

Reactant 3

HCID 962WaterHCID 15793OctadecylamineHCID 2723635(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol hydrochloride

Product 1

HCID 70443965HCID 70443965, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

6.45 g of D-glucosamine hydrochloride were dissolved in 30 ml of isopropanol and 10 ml of water at 60° C., and 12.1 g of stearylamine were added. The resulting clear solution was subsequently stirred for a further 10 minutes and then cooled to room temperature. The product which crystallized out was filtered off with suction and washed first with ethanol/water (5:2, v/v), then with ethanol and finally with ether. The residue was dried under a high vacuum.

Workup

  1. customThe product which crystallized out
  2. filtrationwas filtered off with suction
  3. washwashed first with ethanol/water (5:2
  4. customThe residue was dried under a high vacuum

Sources & evidence

ORD record
ord-12e85c2605ad4453a86728ee36a9bac6
Source dataset
uspto-grants-1987_12
Patent number
US04710491

Reaction notes

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