反应详情

A 100-ml 4-neck flask was charged with 3.74 g of NaH (containing 50% of oil) and 50 ml of N,N-dimethylformamide, and a solution of 15.46 g of hydroquinone monobenzyl ether in 30 ml of N,N-dimethylformamide was added under a nitrogen current over a period of 20 minutes in an ice water bath. After 20 minutes, 16 g of optically active 1-bromo-6-methyloctane was added over a period of 45 minutes, and reaction was carried out at room temperature for 6 hours. The reaction mixture was extracted with ether. The ether layer was washed with water, 5% NaOH, water and a saturated aqueous solution of sodium chloride in sequence and dried, and the organic solvent was distilled under reduced pressure to obtain a crude product. The crude product was purified to obtain 24.37 g of an ether compound.

1. customreaction
2. waitwas carried out at room temperature for 6 hours
3. extractionThe reaction mixture was extracted with ether
4. washThe ether layer was washed with water, 5% NaOH, water
5. dry with materiala saturated aqueous solution of sodium chloride in sequence and dried
6. distillationthe organic solvent was distilled under reduced pressure
7. customto obtain a crude product
8. customThe crude product was purified
9. customto obtain 24.37 g of an ether compound