Hydrochloric Acid → HCID 178479735, compound

HRID 986211Notes

Reaction equation

HRID 986211 reaction equation
[O:1]([CH2:8][CH:9]([OH:15])[CH2:10][NH:11][CH2:12][CH2:13][NH2:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH:16][C:17]1(C(OCC)=O)[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)C=[N:19][NH:18]1.[ClH:32].CC[O:35][CH2:36][CH3:37]>>[ClH:32].[O:1]([CH2:8][CH:9]([OH:15])[CH2:10][NH:11][CH2:12][CH2:13][NH:14][C:36]([C:37]1[C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:17]([SH:16])=[N:18][N:19]=1)=[O:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 145507661-[(2-Aminoethyl)amino]-3-phenoxypropan-2-olHCID 20158266HCID 20158266, compound

Product 1

HCID 178479735HCID 178479735, compound

Conditions

Temperature
95 °C

Procedure

An intimate mixture of 1-phenoxy-3-β-aminoethylamino-2-propanol (4.2 g.) and ethyl 4-mercaptophthalazine-4-carboxylate (2.3 g.) is heated at 95° C. for 1 hour, cooled, powdered and stirred with a mixture of aqueous 2N-hydrochloric acid and ether. The mixture is filtered and there is thus obtained as solid residue 1-phenoxy-3-β-(4-mercaptophthalazine-1-carboxamido)ethylamino-2-propanol hydrochloride, m.p. 232°-236° C., which is used without further purification.

Workup

  1. temperaturecooled
  2. filtrationThe mixture is filtered

Sources & evidence

ORD record
ord-79b5aa12813c4696a1d9957438668c80
Source dataset
uspto-grants-1987_12
Patent number
US04711887

Reaction notes

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