Potassium Carbonate → 2-{4-[2-(4-Fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidyl}-1-(4-fluorophenyl)-1-propanone

HRID 986259Notes

Reaction equation

HRID 986259 reaction equation
Br[CH:2]([CH3:12])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[F:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2([CH:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[O:24][CH2:23][CH2:22][O:21]2)=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[F:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2([CH:25]3[CH2:30][CH2:29][N:28]([CH:2]([CH3:12])[C:3]([C:5]4[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=4)=[O:4])[CH2:27][CH2:26]3)[O:24][CH2:23][CH2:22][O:21]2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 130516522-Bromo-1-(4-fluorophenyl)propan-1-oneHCID 132790992-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolane

Product 1

HCID 201584592-{4-[2-(4-Fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidyl}-1-(4-fluorophenyl)-1-propanone

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The reaction is performed under the conditions of Example 4a, starting with 9.24 g (0.04 mole) of 2-bromo-1-(4-fluorophenyl)-1-propanone, 10.05 g (0.04 mole) of 2-(4-fluorophenyl)-2-(4-piperidyl)1,3-dioxolane and 5.56 g of potassium carbonate in 150 ml of acetonitrile.

Sources & evidence

ORD record
ord-8b283410461c45ed90d138e288973eb1
Source dataset
uspto-grants-1987_12
Patent number
US04711899

Reaction notes

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