Water → HCID 14031943, compound

HRID 986510Notes

Reaction equation

HRID 986510 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[C:7](SC#N)[N:6]3[N:15]=[C:16]([C:18]4[O:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[C:5]3[C:4]=2[CH:3]=1.[C:23]([NH2:27])([CH3:26])([CH3:25])[CH3:24].O>CN1CCN(C)C1=O.C(O)C>[C:23]([NH:27][C:7]1[N:6]2[N:15]=[C:16]([C:18]3[O:19][CH:20]=[CH:21][CH:22]=3)[N:17]=[C:5]2[C:4]2[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:9]=2[N:8]=1)([CH3:26])([CH3:25])[CH3:24]

Participants

6

Reactant 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 14086191HCID 14086191, compound

Product 1

HCID 14031943HCID 14031943, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 66611,3-Dimethyl-2-imidazolidinoneSolvent

Procedure

A solution of 9-chloro-5-thiocyanato-2-(2-furyl)[1,2,4]triazolo-[1,5-c]quinazoline (2 g) in 1,3-dimethylimidazolidone (28 ml) is added to tert-butylamine (2 ml). The mixture is stirred for 3 hours under nitrogen, and then is diluted with ethanol (20 ml), and treated with water (20 ml). The resulting precipitate is collected, recrystallized from 2-methoxyethanol, and dried in high vacuum to afford pure 5-tert-butylamino-9-chloro-2-(2-furyl)-[1,2,4]triazolo-[1,5-c]quinazoline, mp above 330° C.

Workup

  1. customThe resulting precipitate is collected
  2. customrecrystallized from 2-methoxyethanol
  3. customdried in high vacuum

Sources & evidence

ORD record
ord-0157a583b1534bbca7cc7537d69f4b1f
Source dataset
uspto-grants-1987_12
Patent number
US04713383

Reaction notes

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