Lithium Hydroxide → HCID 20157948, compound

HRID 986561Notes

Reaction equation

HRID 986561 reaction equation
[C:1]([C:9]1[CH:23]=[CH:22][CH:21]=[CH:20][C:10]=1[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH-].[Li+]>>[C:1]([C:9]1[CH:23]=[CH:22][CH:21]=[CH:20][C:10]=1[O:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 20157956HCID 20157956, compound

Product 1

HCID 20157948HCID 20157948, compoundYield 99%

Procedure

Ethyl 4-[2-(1-octynyl)-phenoxy]-butanoate, (250 mg, 0.79 mmole) was hydrolysed with 1 molar equivalent of lithium hydroxide using the same procedure as in example 9. Purification of the crude material by chromatography using silica gel, eluting with chloroform to chloroform/5% methanol afforded the title compound in 99% yield as a colourless oil.

Workup

  1. customPurification of the crude material by chromatography
  2. washeluting with chloroform to chloroform/5% methanol

Sources & evidence

ORD record
ord-d8a1c94129ea4bdcbbfdcaa58a1a2987
Source dataset
uspto-grants-1987_12
Patent number
US04713486

Reaction notes

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