反应详情

13.6 g (83 mmol) of carbonyldiimidazole are added to 33.0 g (83 mmol) of 4-(2-chloro-6-fluorophenyl)-3-cyclopentyloxycarbonyl-1.4-dihydro-2,6-dimethylpyridine-5-carboxylic acid in 350 ml of tetrahydrofuran and the mixture is heated to reflux for 3 h. Thin-layer chromatographic checking (silica gel, toluene/ethyl acetate 1:1) shows complete reaction, after which the reaction mixture is concentrated, the residue is taken up in ethyl acetate, and the solution is washed twice with water, dried over sodium sulphate and concentrated again. The target compound precipitates from ether in the form of white crystals of m.p. 150° C.

1. temperaturethe mixture is heated
2. temperatureto reflux for 3 h
3. customreaction
4. concentrationafter which the reaction mixture is concentrated
5. washthe solution is washed twice with water
6. dry with materialdried over sodium sulphate
7. concentrationconcentrated again
8. customThe target compound precipitates from ether in the form of white crystals of m.p. 150° C.