Hydrochloric Acid → HCID 12138349, compound

HRID 987175Notes

Reaction equation

HRID 987175 reaction equation
CN(C)C([S:5][C:6]1[CH:7]=[C:8]([CH:13]=[C:14]([S:16]C(=O)N(C)C)[CH:15]=1)[C:9]([O:11][CH3:12])=[O:10])=O.C[O-].[Na+].Cl>CO>[SH:5][C:6]1[CH:7]=[C:8]([CH:13]=[C:14]([SH:16])[CH:15]=1)[C:9]([O:11][CH3:12])=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 12138342Methyl 3,5-bis(dimethylcarbamoylthio)benzoate

Product 1

HCID 12138349HCID 12138349, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methyl 3,5-bis(dimethylcarbamoylthio)benzoate (34.2 g, 0.10 mol) was made to react with a mixture of 43 g of 28% methanol solution of sodium methoxide (0.223 mol) and methanol (150 ml) at 22-25° C. After addition of 500 ml of ice-water, the reaction mixture was neutralized with concentrated hydrochloric acid to give a colorless crystals. The crystals thus obtained were purified by means of recrystallization from methanol giving 12.5 g (62.5%) of methyl 3,5-dimercaptobenzoate as a colorless powder. The melting point is 61-62° C.

Workup

  1. customto give a colorless crystals
  2. customThe crystals thus obtained
  3. customwere purified by means of recrystallization from methanol giving 12.5 g (62.5%) of methyl 3,5-dimercaptobenzoate as a colorless powder

Sources & evidence

ORD record
ord-83dde45f58174b06bd96bd0b186856b4
Source dataset
uspto-grants-2003_10
Patent number
US06630578B2

Reaction notes

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