反应详情

3-(4-Benzyloxyphenyl)-2-phenoxypropanoic acid methyl ester (0.47 g; 1.3 mmole) was hydrogenated in ethyl acetate (20 ml) using Pd/C (18 mg; 5%) as catalyst at atmospheric pressure and room temperature for 23 hours. As the reaction was very slow, the catalyst was changed to palladium hydroxide, ethanol (95%, 10 ml) was added and the pressure was raised to 4 bar. The reaction mixture was filtered through celite and the filtrate was concentrated in vacuo to give 0.34 g (yield 95%) of 3-(4-hydroxyphenyl)-2-phenoxypropanoic acid methyl ester.

1. customat atmospheric pressure and room temperature
2. customfor 23 hours
3. additionwas added
4. temperaturethe pressure was raised to 4 bar
5. filtrationThe reaction mixture was filtered through celite
6. concentrationthe filtrate was concentrated in vacuo