反应详情

A mixture of 12-bromododecan-1-ol (15 g, 57 mmol, see Example 1 above), 4-hydroxy-benzaldehyde (6.9 g, 57 mmol), potassium carbonate (excess), potassium iodide (trace) and tetra-n-butylammonium iodide (trace) was heated at reflux in methyl ethyl ketone (50 ml) for 16 hours. After cooling, the solids were filtered off and washed with acetone. The combined organic fractions were evaporated to dryness. Diethyl ether was added to the resultant oil and the solution was stored at 4° C. The title compound precipitated and was collected by filtration.

1. temperaturewas heated
2. temperatureAfter cooling
3. filtrationthe solids were filtered off
4. washwashed with acetone
5. customThe combined organic fractions were evaporated to dryness
6. additionDiethyl ether was added to the resultant oil
7. customwas stored at 4° C
8. customThe title compound precipitated
9. filtrationwas collected by filtration