Ethyl isocyanate → HCID 178465301, compound

HRID 987399Notes

Reaction equation

HRID 987399 reaction equation
[C:1]1([C:7]2[CH:16]=[CH:15][C:10]3[NH:11][C:12]([NH2:14])=[N:13][C:9]=3[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([N:19]=[C:20]=[O:21])[CH3:18]>C1COCC1>[CH2:17]([NH:19][C:20]([NH:14][C:12]1[NH:11][C:10]2[CH:15]=[CH:16][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][C:9]=2[N:13]=1)=[O:21])[CH3:18]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 178508149HCID 178508149, compound

Product 1

HCID 178465301HCID 178465301, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 7 (40 mg, 0.19 mmol) in THF (1 mL) was added ethyl isocyanate (27 μL, 0.34 mmol) as a solution in THF (0.5 mL). The reaction was heated to reflux overnight then concentrated in vacuo. The crude product was purified by preparative HPLC to afford Ia-84.

Workup

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. concentrationthen concentrated in vacuo
  4. customThe crude product was purified by preparative HPLC
  5. customto afford Ia-84

Sources & evidence

ORD record
ord-b2dbc2836e5443b5bb2b2275fc41eaca
Source dataset
uspto-grants-2003_10
Patent number
US06632809B2

Reaction notes

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