反应详情

温度

50 °C

To a solution of 5-nitrobenzo-2,1,3-thiadiazole in a mixture of dioxane (22 mL) and ethanol (22 mL) at RT added solid SnCl2 followed by addition of water (1 mL). The reaction mixture was warmed up to 50° C. and stirred for 10 min, cooled to RT, concentrated and partitioned between ethyl acetate/1 N NaOH. The organic layer was washed with 1N NaOH, water, brine, dried over MgSO4 and charcoal. Evaporation of the solvent gave 5-aminobenzo-2,1,3-thiadiazole as a yellow powder (3.0 g, 88%).

1. temperaturecooled to RT
2. concentrationconcentrated
3. custompartitioned between ethyl acetate/1 N NaOH
4. washThe organic layer was washed with 1N NaOH, water, brine
5. dry with materialdried over MgSO4 and charcoal
6. customEvaporation of the solvent