1-Phenylpiperazine → 2,7-Bis-[3-(4-phenyl-piperazin-1-yl)propionyl]-xanthene

HRID 988869Notes

Reaction equation

HRID 988869 reaction equation
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:19]=[CH:18][C:17]2[O:16][C:15]3[C:10](=[CH:11][C:12]([C:20](=[O:24])[CH2:21][CH2:22]Cl)=[CH:13][CH:14]=3)[CH2:9][C:8]=2[CH:7]=1)=[O:5].[C:25]1([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[C:25]1([N:31]2[CH2:36][CH2:35][N:34]([CH2:2][CH2:3][C:4]([C:6]3[CH:19]=[CH:18][C:17]4[O:16][C:15]5[C:10](=[CH:11][C:12]([C:20](=[O:24])[CH2:21][CH2:22][N:34]6[CH2:35][CH2:36][N:31]([C:25]7[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=7)[CH2:32][CH2:33]6)=[CH:13][CH:14]=5)[CH2:9][C:8]=4[CH:7]=3)=[O:5])[CH2:33][CH2:32]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 70961-PhenylpiperazineHCID 123402792,7-Bis(3-chloropropionyl)xanthene

Product 1

HCID 101217392,7-Bis-[3-(4-phenyl-piperazin-1-yl)propionyl]-xanthene

Procedure

Prepared from compound 17 and 4-phenyl-piperazine according to General Procedure C to give a solid. Mp 206-208° C. 1H NMR (CDCl3, 400 MHz) δ7.91-7.86 (m 4H), 7.29 (t, J=10 Hz, 4H), 7.14 (d, J=10 Hz, 2H), 6.96-6.91 (m, 6H), 4.16 (s, 2H), 3.51-3.46 (m, 12H), 3.38-3.10 (m, 12H). Anal. (C39H42N4O3.).

Workup

  1. customto give a solid

Sources & evidence

ORD record
ord-bdbfa8efd9974e3ba4131474d38c92b9
Source dataset
uspto-grants-2003_10
Patent number
US06635786B2

Reaction notes

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