Triethylamine → HCID 11514448, compound

HRID 988917Notes

Reaction equation

HRID 988917 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=1.[N:12]1([CH2:17][CH2:18][CH2:19][NH2:20])[CH:16]=[CH:15][N:14]=[CH:13]1.C(N(CC)CC)C>COCCOC>[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 787361H-Imidazole-1-propanamineHCID 949565-Fluoro-2-nitrotoluene

Product 1

HCID 11514448HCID 11514448, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 31.2 g (0.2 mol) of 4-fluoro-2-methyl-1-nitrobenzene, 37.5 g (0.3 mol) of 3-imidazol-1-ylpropylamine and 34.8 ml (0.25 mol) of triethylamine in 30 ml of 1,2-dimethoxyethane was heated with stirring for 3 hours on a boiling water bath.

Workup

  1. temperaturewas heated

Sources & evidence

ORD record
ord-bf40319dd25340ba85eb71cf9be17ffa
Source dataset
uspto-grants-2003_10
Patent number
US06638321B1

Reaction notes

Loading…