2-Aminopyrimidine → HCID 9816809, compound

HRID 988996Notes

Reaction equation

HRID 988996 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]([N+:12]#[C-:13])([CH3:11])([CH3:10])[CH3:9].[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH:20]=O)[CH:15]=1>Cl(O)(=O)(=O)=O>[C:8]([NH:12][C:13]1[N:3]2[CH:4]=[CH:5][CH:6]=[N:7][C:2]2=[N:1][C:20]=1[C:16]1[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=1)([CH3:11])([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 103713-PyridinecarboxaldehydeHCID 23577Tert-Butyl isocyanide

Product 1

HCID 9816809HCID 9816809, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (17) was prepared in accordance with general instructions 1 from 1.0 ml 2-aminopyrimidine solution (0.1 M, MC), 0.575 ml tert-butylisonitrile solution (0.2 M, MC), 0.500 ml pyridine-3-carbaldehyde solution (0.3 M, MC), and 10 μl perchloric acid (w=20%).

Sources & evidence

ORD record
ord-382a73c98d2747ffa1cf96856e8b1583
Source dataset
uspto-grants-2003_10
Patent number
US06638933B2

Reaction notes

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