2-Aminopyrimidine → HCID 18004775, compound

HRID 988998Notes

Reaction equation

HRID 988998 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][C:9]([N+:16]#[C-:17])([CH3:15])[CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12].[NH:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH:23]=O>Cl(O)(=O)(=O)=O>[NH:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23]1[N:1]=[C:2]2[N:7]=[CH:6][CH:5]=[CH:4][N:3]2[C:17]=1[NH:16][C:9]([CH3:15])([CH3:8])[CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 13854Pyrrole-2-carboxaldehydeHCID 267251,1,3,3-Tetramethylbutyl isocyanide

Product 1

HCID 18004775HCID 18004775, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (19) was prepared in accordance with general instructions 1 from 1.0 ml 2-aminopyrimidine solution (0.1 M, MC), 0.575 ml 1,1,3,3-tetramethylbutyl isocyanide solution (0.2 M, MC), 0.500 ml pyrrole-2-carbaldehyde solution (0.3 M, MC), and 10 μl perchloric acid (w=20%).

Sources & evidence

ORD record
ord-8131e905457c43aaa47351e35eeb51fa
Source dataset
uspto-grants-2003_10
Patent number
US06638933B2

Reaction notes

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