2-Aminopyrimidine → HCID 9861826, compound

HRID 989000Notes

Reaction equation

HRID 989000 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]([N+:12]#[C-:13])([CH3:11])([CH3:10])[CH3:9].N#[C-].[CH3:16][S:17][C:18]1[S:22][C:21]([CH:23]=O)=[CH:20][CH:19]=1>Cl(O)(=O)(=O)=O>[C:8]([NH:12][C:13]1[N:3]2[CH:4]=[CH:5][CH:6]=[N:7][C:2]2=[N:1][C:23]=1[C:21]1[S:22][C:18]([S:17][CH3:16])=[CH:19][CH:20]=1)([CH3:11])([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 27369975-(Methylsulfanyl)thiophene-2-carbaldehydeHCID 86587200HCID 86587200, compound

Product 1

HCID 9861826HCID 9861826, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (26) was prepared in accordance with general instructions 1 from 1.0 ml 2-aminopyrimidine solution (0.1 M, MC), 0.575 ml tert-butylisonitrile isocyanide solution (0.2 M, MC), 0.500 ml 5-methylsulfanyl-thiophene-2-carbaldehyde solution (0.3 M, MC), and 10 μl perchloric acid (w=20%). Calculated mass 318.5; found mass 319.2 (ESI-MS)

Sources & evidence

ORD record
ord-9ed0afd657274934b001bb3cfaa9a5e3
Source dataset
uspto-grants-2003_10
Patent number
US06638933B2

Reaction notes

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