2-Aminopyridine → HCID 18004783, compound

HRID 989001Notes

Reaction equation

HRID 989001 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:8]1([N+:14]#[C-:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[Br:16][C:17]1[CH:21]=[CH:20][S:19][C:18]=1[CH:22]=O>Cl(O)(=O)(=O)=O>[Br:16][C:17]1[CH:21]=[CH:20][S:19][C:18]=1[C:22]1[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]2[C:15]=1[NH:14][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 104392-AminopyridineHCID 79129Cyclohexyl isocyanideHCID 27970793-Bromothiophene-2-carboxaldehyde

Product 1

HCID 18004783HCID 18004783, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (27) was prepared in accordance with general instructions 1 from 1.0 ml 2-aminopyridine solution (0.1 M, MC), 0.575 ml cyclohexyl isocyanide solution (0.2 M, MC), 0.500 ml 3-bromothiophene-2-carbaldehyde solution (0.3 M, MC), and 10 μl perchloric acid (w=20%). Calculated mass 376.3; found mass 376.4/378.3 (ESI-MS)

Sources & evidence

ORD record
ord-d11e78407fb14760bef3fa8891cb2269
Source dataset
uspto-grants-2003_10
Patent number
US06638933B2

Reaction notes

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