2-Aminopyrimidine → HCID 18004778, compound

HRID 989003Notes

Reaction equation

HRID 989003 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][C:9]([N+:16]#[C-:17])([CH3:15])[CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12].[Cl:18][C:19]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:20]=1[CH:21]=O>Cl(O)(=O)(=O)=O>[Cl:18][C:19]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:20]=1[C:21]1[N:1]=[C:2]2[N:7]=[CH:6][CH:5]=[CH:4][N:3]2[C:17]=1[NH:16][C:9]([CH3:15])([CH3:8])[CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 267251,1,3,3-Tetramethylbutyl isocyanideHCID 1450242-Chloro-4-fluorobenzaldehyde

Product 1

HCID 18004778HCID 18004778, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (29) was prepared in accordance with general instructions 1 from 1.0 ml 2-aminopyrimidine solution (0.1 M, MC), 0.575 ml 1,1,3,3-tetramethylbutyl isocyanide solution (0.2 M, MC), 0.500 ml 2-chloro-4-fluorobenzaldehyde solution (0.3 M, MC), and 10 μl perchloric acid (w=20%). Calculated mass 374.9; found mass 375.3 (ESI-MS)

Sources & evidence

ORD record
ord-167e355bad2142b9abcca835bc40bc87
Source dataset
uspto-grants-2003_10
Patent number
US06638933B2

Reaction notes

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