反应详情

温度

50 °C

A suspension of 1.00 g of 4-(tert-butoxycarbonylamino)piperidine and 0.72 ml of triethylamine in 6 ml of dry N,N-dimethylformamide was stirred at an inner temperature of 50° C., and added dropwise with a solution of 0.79 g of n-butyl chloroacetate in 4 ml of dry N,N-dimethylformamide. Stirring was continued at the same temperature for 1 hour. Then, the reaction mixture was added with water, and the precipitated crystals were collected by filtration. The crystals were washed successively with water and n-heptane to obtain 1.46 g of colorless scales (mp: 115.5-116.5° C.).

1. stirringStirring
2. filtrationthe precipitated crystals were collected by filtration
3. washThe crystals were washed successively with water and n-heptane
4. customto obtain 1.46 g of colorless scales (mp: 115.5-116.5° C.)