反应详情

A solution of hydrogen chloride in isopropanol (6 ml) was added to 1.35 g of n-butyl 4-tert-butoxycarbonylamino-1-piperidineacetate, and the mixture was stirred at room temperature for 15 minutes. The solvent was evaporated, and the residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine. The precipitated solid was filtered off, and the solvent of the filtrate was evaporated to obtain 1.04 g of colorless oil.

1. customThe solvent was evaporated
2. additionthe residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine
3. filtrationThe precipitated solid was filtered off
4. customthe solvent of the filtrate was evaporated