Hydrochloric Acid → Butyl 2-(4-aminopiperidin-1-yl)acetate

HRID 989131Notes

Reaction equation

HRID 989131 reaction equation
Cl.C(OC([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:12][CH2:11]1)=O)(C)(C)C>C(O)(C)C>[NH2:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:16][C:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:18])[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10710390Butyl 4-tert-butoxycarbonylamino-1-piperidineacetate

Product 1

HCID 10608685Butyl 2-(4-aminopiperidin-1-yl)acetateYield 113%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of hydrogen chloride in isopropanol (6 ml) was added to 1.35 g of n-butyl 4-tert-butoxycarbonylamino-1-piperidineacetate, and the mixture was stirred at room temperature for 15 minutes. The solvent was evaporated, and the residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine. The precipitated solid was filtered off, and the solvent of the filtrate was evaporated to obtain 1.04 g of colorless oil.

Workup

  1. customThe solvent was evaporated
  2. additionthe residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine
  3. filtrationThe precipitated solid was filtered off
  4. customthe solvent of the filtrate was evaporated

Sources & evidence

ORD record
ord-f71207a466a24340ba02c0001e1c1d0c
Source dataset
uspto-grants-2003_10
Patent number
US06638951B1

Reaction notes

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