Hydrochloric Acid → 4-(4-Methylpiperazin-1-yl)-6-{2-[(6-pyrrolidin-1-ylpyridin-3-yl)acetyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}pyrimidin-2-amine
Reaction equation
[CH3:4][N:5]1[CH2:6][CH2:7][N:8]([c:11]2[n:12][c:13]([NH2:27])[n:14][c:15](-[c:17]3[cH:18][cH:19][c:20]4[c:25]([cH:26]3)[CH2:24][NH:23][CH2:22][CH2:21]4)[cH:16]2)[CH2:9][CH2:10]1.[CH3:55][CH2:56][N:57]([CH2:58][CH3:59])[CH2:60][CH3:61].[ClH:1].[ClH:2].[ClH:3].[N:62]1([c:67]2[cH:68][cH:69][c:70]([CH2:73][C:74](=[O:75])[OH:76])[cH:71][n:72]2)[CH2:63][CH2:64][CH2:65][CH2:66]1.[P-:28]([F:29])([F:30])([F:31])([F:32])([F:33])[F:34].[n:35]1([O:36][P+:37]([N:38]([CH3:39])[CH3:40])([N:41]([CH3:42])[CH3:43])[N:44]([CH3:45])[CH3:46])[c:47]2[cH:48][cH:49][cH:50][cH:51][c:52]2[n:53][n:54]1>>[CH3:4][N:5]1[CH2:6][CH2:7][N:8]([c:11]2[n:12][c:13]([NH2:27])[n:14][c:15](-[c:17]3[cH:18][cH:19][c:20]4[c:25]([cH:26]3)[CH2:24][N:23]([C:74]([CH2:73][c:70]3[cH:69][cH:68][c:67]([N:62]5[CH2:63][CH2:64][CH2:65][CH2:66]5)[n:72][cH:71]3)=[O:75])[CH2:22][CH2:21]4)[cH:16]2)[CH2:9][CH2:10]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-b111331fbb304599ae673b72a9b3f6df
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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