5-Methoxy-6-(trifluoromethyl)indoline → HCID 10767350, compound

HRID 989211Notes

Reaction equation

HRID 989211 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)[CH:10]=[C:11]([NH:13][C:14](=[O:22])OC3C=CC=CC=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:29][O:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][C:39]=1[C:40]([F:43])([F:42])[F:41])[NH:36][CH2:35][CH2:34]2>CN(C=O)C>[CH3:29][O:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][C:39]=1[C:40]([F:43])([F:41])[F:42])[N:36]([C:14](=[O:22])[NH:13][C:11]1[CH:12]=[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH:8]=[C:9]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)[CH:10]=1)[CH2:35][CH2:34]2

Participants

4

Reactant 2

HCID 112067135-Methoxy-6-(trifluoromethyl)indolineHCID 18005096HCID 18005096, compound

Product 1

HCID 10767350HCID 10767350, compoundYield 198.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound (0.74 g, 47%) was prepared as an off white solid using the methodology of example 28, with phenyl N-(5-phenyl-3-(pyrid-3-yl)phenyl)carbamate (D31) (0.27 g, 0.76 mmol) and 5-methoxy-6-trifluoromethyl indoline (D11) [0.182 mg, 0.83 mmol] in DMF (10 ml). Melting point: 150°-151° C.

Sources & evidence

ORD record
ord-7414e02a6cf7406889a98a5594f8069f
Source dataset
uspto-grants-2003_10
Patent number
US06638953B2

Reaction notes

Loading…