Pyrrolidine → 1-[4-(3,5-Dichloro-phenoxy)-benzyl]-pyrrolidine

HRID 989264Notes

Reaction equation

HRID 989264 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([Cl:17])[CH:16]=1)[O:5][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=1.[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([Cl:17])[CH:16]=1)[O:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 162440874-(3,5-Dichlorophenoxy)benzaldehyde

Product 1

HCID 98368361-[4-(3,5-Dichloro-phenoxy)-benzyl]-pyrrolidine

Procedure

The title compound was prepared starting from 4-(3,5-dichloro-phenoxy)-benzaldehyde and pyrrolidine by the same method (step B) described in Example 1. 1H NMR (400 MHz, CDCI3)δ7.22 (t, J=7.8 Hz, 1 H), 7.07 (d, J=7.6 Hz,1 H), 6.96 (m, 2 H), 6.81 (m,1 H), 6.76 (m, 2 H), 3.52 (s, 2 H), 2.45 (m, 4 H), 1.70 (m, 4 H).

Sources & evidence

ORD record
ord-8be90798025a4f9eb3529acf116cd19b
Source dataset
uspto-grants-2003_10
Patent number
US06638967B2

Reaction notes

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