Sodium ion → Tert-butyl 3-(5-bromo-2-chloropyrimidin-4-yloxy)azetidine-1-carboxylate

HRID 98941Notes

Reaction equation

HRID 98941 reaction equation
[Br:15][c:16]1[c:17]([Cl:23])[n:18][c:19]([Cl:22])[n:20][cH:21]1.[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[H-:14].[Na+:13].[OH:1][CH:2]1[CH2:3][N:4]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH2:5]1>>[O:1]([CH:2]1[CH2:3][N:4]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH2:5]1)[c:17]1[c:16]([Br:15])[cH:21][n:20][c:19]([Cl:22])[n:18]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 8028TetrahydrofuranHCID 166653HydrideHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 2756801Tert-butyl 3-hydroxyazetidine-1-carboxylate

Product 1

HCID 86761723Tert-butyl 3-(5-bromo-2-chloropyrimidin-4-yloxy)azetidine-1-carboxylate

Sources & evidence

ORD record
ord-ca50f803be194ca7bb549f6e4aaf2ed2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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