反应详情

Methyl triphenylphosphoranylideneacetate (500 mg) was added to a solution of 150 mg of 7-formylimidazo[5,1-b]thiazole in 15 ml of methanol. The mixture was stirred at room temperature for 15 min. Ethyl acetate was added thereto. The mixture was washed with water, dried over anhydrous magnesium sulfate, and filtered. The solvent was removed by distillation under the reduced pressure. The residue was purified by column chromatography on silica gel (chloroform:methanol=20:1) to give 228 mg of 7-(2-methoxycarbonylvinyl)imidazo[5,1-b]thiazole (a mixture of geometrical isomers).

1. washThe mixture was washed with water
2. dry with materialdried over anhydrous magnesium sulfate
3. filtrationfiltered
4. customThe solvent was removed by distillation under the reduced pressure
5. customThe residue was purified by column chromatography on silica gel (chloroform:methanol=20:1)