Thiophenol → HCID 18672845, compound

HRID 990200Notes

Reaction equation

HRID 990200 reaction equation
Cl[C:2]1[CH:31]=[CH:30][C:5]2=[N:6][N:7]([C:9]3[CH:14]=[C:13]([C:15]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:17])[CH3:16])[CH:12]=[C:11]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:10]=3[OH:29])[N:8]=[C:4]2[CH:3]=1.[OH-].[K+].[C:34]1([SH:40])[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>CN1CCCC1=O>[C:34]1([S:40][C:2]2[CH:31]=[CH:30][C:5]3=[N:6][N:7]([C:9]4[CH:14]=[C:13]([C:15]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:17])[CH3:16])[CH:12]=[C:11]([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[C:10]=4[OH:29])[N:8]=[C:4]3[CH:3]=2)[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 14797Potassium HydroxideHCID 18672841HCID 18672841, compound

Product 1

HCID 18672845HCID 18672845, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The title compound is prepared according to the procedure of Example 4 from 20 g of the compound of Example 8, 20.4 g of 45% aqueous potassium hydroxide, 10.3 g of thiophenol and 100 g of N-methylpyrrolidone. The title compound is an oil purified by chromatography on silica gel using toluene as eluent.

Workup

  1. customThe title compound is prepared
  2. custompurified by chromatography on silica gel

Sources & evidence

ORD record
ord-a736b00a14f64269890b0fbea9f6b6b7
Source dataset
uspto-grants-2002_10
Patent number
US06458872B1

Reaction notes

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