Hydrochloric Acid → 5-n-Butylthio-2-(2-hydroxy-3-alpha-cumyl-5-tert-octylphenyl)-2H-benzotriazole

HRID 990205Notes

Reaction equation

HRID 990205 reaction equation
Cl[C:2]1[CH:34]=[CH:33][C:5]2=[N:6][N:7]([C:9]3[CH:14]=[C:13]([C:15]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:17])[CH3:16])[CH:12]=[C:11]([C:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)([CH3:25])[CH3:24])[C:10]=3[OH:32])[N:8]=[C:4]2[CH:3]=1.[CH2:35]([SH:39])[CH2:36][CH2:37][CH3:38].[OH-].[K+].CN1CCCC1=O.Cl>>[CH2:35]([S:39][C:2]1[CH:34]=[CH:33][C:5]2=[N:6][N:7]([C:9]3[CH:14]=[C:13]([C:15]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:17])[CH3:16])[CH:12]=[C:11]([C:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)([CH3:25])[CH3:24])[C:10]=3[OH:32])[N:8]=[C:4]2[CH:3]=1)[CH2:36][CH2:37][CH3:38]

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 8012ButanethiolHCID 13387N-methyl-2-pyrrolidoneHCID 14797Potassium HydroxideHCID 218850095-chloro-2-(2-hydroxy-3-alpha-cumyl-5-tertoctylphenyl)-2H-benzotriazole

Product 1

HCID 186728385-n-Butylthio-2-(2-hydroxy-3-alpha-cumyl-5-tert-octylphenyl)-2H-benzotriazoleYield 83%

Procedure

5-Chloro-2-(2-hydroxy-3-α-cumyl-5-tert-octylphenyl)-2H-benzotriazole (38.1 g, 0.08 mol), n-butyl mercaptan (9 g, 0.10 mol), potassium hydroxide (10.1 g, 0.18 mol) and N-methylpyrrolidone (99 g, 1.0 mol) are charged to a reactor and heated to 170°0C. The reaction mass is held at 170° C. with vigorous stirring for five hours. The reaction is judged as complete using thin layer chromatography. The temperature is reduced to 5° C. and 100 mL of aqueous 2N hydrochloric acid are then added to the reactor. The liquid is decanted and the solids are dissolved in ethyl acetate. The organic layer is washed with aqueous 2N hydrochloric acid followed by water. The ethyl acetate is stripped off and the product is crystallized from ethanol and toluene. The title compound is obtained as a yellow crystalline product in 83% yield. The structure is verified by 1Hnmr.

Workup

  1. temperatureheated to 170°0C
  2. customis held at 170° C.
  3. customis reduced to 5° C.
  4. customThe liquid is decanted
  5. dissolutionthe solids are dissolved in ethyl acetate
  6. washThe organic layer is washed with aqueous 2N hydrochloric acid
  7. customthe product is crystallized from ethanol and toluene

Sources & evidence

ORD record
ord-c2ad1ae793564f0e9ff46f3c868c145f
Source dataset
uspto-grants-2002_10
Patent number
US06458872B1

Reaction notes

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