Potassium Iodide → HCID 11817999, compound

HRID 990570Notes

Reaction equation

HRID 990570 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:7]=1[OH:15])(=[O:3])[CH3:2].Cl[CH2:17][C:18]([NH2:20])=[O:19].C(=O)([O-])[O-].[Ca+2].[I-].[K+]>CC(C)=O.O>[C:1]([NH:4][CH2:5][C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:7]=1[O:15][CH2:17][C:18]([NH2:20])=[O:19])(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 6580ChloroacetamideHCID 10112Calcium CarbonateHCID 3351402-Acetamidomethyl-4-nitrophenol

Product 1

HCID 11817999HCID 11817999, compoundYield 71.8%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

131.4 g of 2-acetylaminomethyl-4-nitrophenol, 64.4 g of chloroacetamide, 86.4 g of calcium carbonate and 57.1 g of potassium iodide in 800 ml of acetone are heated under reflux for four hours. Subsequently the reaction mixture is cooled to room temperature and poured into 1300 ml of water. The resulting precipitate is filtered, washed with water and subsequently dried. 120 g of a yellow product are obtained having a melting point of from 236 to 240° C.

Workup

  1. temperatureunder reflux for four hours
  2. filtrationThe resulting precipitate is filtered
  3. washwashed with water
  4. customsubsequently dried

Sources & evidence

ORD record
ord-723bdf933ad1471cb7c98c08c9323ed1
Source dataset
uspto-grants-2002_10
Patent number
US06461390B1

Reaction notes

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