反应详情

To a solution of 2,6-dichloro-4-nitrophenol (2.5 g) and potassium carbonate (3.3 g) in dimethyl-formamide (50 mL) is added tert-butyl-bromoacetate (10 mL) and the mixture is stirred at room temperature for two days. The solution is then poured into 500 mL water, extracted three times with hexanes, and the pooled organic extracts are washed with saturated aqueous ammonium chloride and then dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure followed by trituration of the resulting oil with hexanes provides the desired product as a white solid.

1. extractionextracted three times with hexanes
2. washthe pooled organic extracts are washed with saturated aqueous ammonium chloride
3. dry with materialdried over anhydrous magnesium sulfate
4. customEvaporation of the solvent under reduced pressure