Piperonal → 1-Isopropyl-6,7-methylenedioxy-4-(3,4-methylenedioxyphenyl)-3,4-dihydroquinazolin-2(1H)-one

HRID 991511노트

반응식

HRID 991511 반응식
[CH:1]([N:4]([C:8]1[CH:13]=[CH:12][C:11]2[O:14][CH2:15][O:16][C:10]=2[CH:9]=1)[C:5]([NH2:7])=[O:6])([CH3:3])[CH3:2].[CH:17]1[C:22]([CH:23]=O)=[CH:21][C:20]2[O:25][CH2:26][O:27][C:19]=2[CH:18]=1>>[CH:1]([N:4]1[C:8]2[C:13](=[CH:12][C:11]3[O:14][CH2:15][O:16][C:10]=3[CH:9]=2)[CH:23]([C:22]2[CH:17]=[CH:18][C:19]3[O:27][CH2:26][O:25][C:20]=3[CH:21]=2)[NH:7][C:5]1=[O:6])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 8438PiperonalHCID 1005551-(1,3-Benzodioxol-5-yl)-1-isopropylurea

생성물 1

HCID 127894771-Isopropyl-6,7-methylenedioxy-4-(3,4-methylenedioxyphenyl)-3,4-dihydroquinazolin-2(1H)-one수율 41%

실험 절차

The title compound was synthesized from N-isopropyl-N-[3,4-(methylenedioxy)phenyl]urea and piperonal by the procedure described in example 10 in 41% yield, mp: 87-89° C. 1H NMR (CDCl3,): 6.77 (s, 3H), 6.68 (s, 1H), 6.28 (s, 1H), 5.96 (s, 2H), 5.92-5.90 (m, 2H), 5.22 (d, J=1.8, 1H), 4.98 (br s, 1H), 4.44 (m, 2H), 1.58-1.54 (m, 6H).

출처 및 근거

ORD 기록
ord-5aec52976ddf459cbd1fbdfde1ce0d3a
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06465472B1

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