L-Tyrosine 1,1-dimethylethyl ester → HCID 57013426, compound

HRID 991760Notes

Reaction equation

HRID 991760 reaction equation
[C:1]([O:5][C:6](=[O:17])[C@H:7]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)[NH2:8])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Rh]>[NH2:8][C@@H:7]([CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]1)[C:6]([O:5][C:1]([CH3:3])([CH3:2])[CH3:4])=[O:17]

Participants

5

Reactant 2

HCID 6950582L-Tyrosine 1,1-dimethylethyl esterHCID 178418361HCID 178418361, compound

Product 1

HCID 57013426HCID 57013426, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 887MethanolSolvent

Procedure

L-Tyrosine tert-butyl ester (0.6 g) was hydrogenated in MeOH, with 10% Rh/Al2O3 under 50 psi of hydrogen at room temperature for 2 days. The reaction mixture was filtered through Celite and the solvent evaporated under reduced pressure to afford the title intermediate as a foam.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-eef00932c1b0431ab82cbd42b4c8ba7f
Source dataset
uspto-grants-2002_10
Patent number
US06465513B1

Reaction notes

Loading…