Piperidine → HCID 49823033, compound

HRID 991840Notes

Reaction equation

HRID 991840 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][C:7](=[O:13])[NH:8]2.[O:14]=[C:15]1[C:20]2=[CH:21][NH:22][C:23]([CH:24]=O)=[C:19]2[CH2:18][CH2:17][NH:16]1.N1CCCCC1>C(O)C>[OH:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[CH:24][C:23]1[NH:22][CH:21]=[C:20]3[C:19]=1[CH2:18][CH2:17][NH:16][C:15]3=[O:14])[C:7](=[O:13])[NH:8]2

Participants

5

Reactant 3

HCID 8082PiperidineHCID 99641894-oxo-4,5,6,7-tetrahydro-2H-pyrrolo[3,4-c]pyridine-1-carbaldehydeHCID 109430044-(2-Hydroxyethyl)indolin-2-one

Product 1

HCID 49823033HCID 49823033, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 4-(2-hydroxy-ethyl)-1,3-dihydro-indol-2-one (35.4 mg, 0.2 mmol), 4-oxo-4,5,6,7-tetrahydro-2H-pyrrolo[3,4-c]pyridine-1-carbaldehyde (32.8 mg, 0.2 mmol) and 0.1 mL of piperidine in ethanol (1 mL) was heated in a sealed tube at 80° C. for 4 hours. The precipitate was collected by vacuum filtration, washed with cold ethanol and dried to give the title compound.

Workup

  1. filtrationThe precipitate was collected by vacuum filtration
  2. washwashed with cold ethanol
  3. customdried

Sources & evidence

ORD record
ord-7c5c0535f17f420fbdaece4808518ff6
Source dataset
uspto-grants-2002_10
Patent number
US06465507B2

Reaction notes

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