Piperidine → HCID 69708048, compound

HRID 991845Notes

Reaction equation

HRID 991845 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:11]([NH2:14])(=[O:13])=[O:12])[CH:8]=2)[NH:3]1.[O:15]=[C:16]1[C:21]2=[CH:22][NH:23][C:24]([CH:25]=O)=[C:20]2[CH2:19][CH2:18][NH:17]1.N1CCCCC1>C(O)C>[O:1]=[C:2]1[C:10](=[CH:25][C:24]2[NH:23][CH:22]=[C:21]3[C:20]=2[CH2:19][CH2:18][NH:17][C:16]3=[O:15])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:11]([NH2:14])(=[O:12])=[O:13])[CH:8]=2)[NH:3]1

Participants

5

Reactant 3

HCID 8082PiperidineHCID 99641894-oxo-4,5,6,7-tetrahydro-2H-pyrrolo[3,4-c]pyridine-1-carbaldehydeHCID 101982322-Oxoindoline-5-sulfonamide

Product 1

HCID 69708048HCID 69708048, compoundYield 82.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide (63 mg, 0.3 mmol), 4-oxo-4,5,6,7-tetrahydro-2H-pyrrolo[3,4-c]pyridine-1-carbaldehyde (50 mg, 0.3 mmol) and 0.1 mL of piperidine in ethanol (1 mL) was heated in a sealed tube at 80° C. for 4 hours. The precipitate was collected by vacuum filtration, washed with cold ethanol and dried to give 89 mg (82%) of the title compound.

Workup

  1. filtrationThe precipitate was collected by vacuum filtration
  2. washwashed with cold ethanol
  3. customdried

Sources & evidence

ORD record
ord-b897164b77e84ad0bc2f746975566202
Source dataset
uspto-grants-2002_10
Patent number
US06465507B2

Reaction notes

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