Sulfuric acid magnesium salt (1:1) → HCID 15224420, compound
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[CH:8][C:7]=1[N+:16]([O-])=O.S([O-])([O-])(=O)=O.[Mg+2]>[Pt].C(OCC)(=O)C>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=[C:4]1[CH2:3][O:2][CH3:1]Participants
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 150 °C
Procedure
4-(2-Methoxyethylamino)-3-nitroquinoline (16.24 g; 0.066 mol) was added to a mixture of ethyl acetate (1500 mL), 5% platinum on carbon (1 g), and magnesium sulfate (6 g). The mixture was hydrogenated on a Parr apparatus at 30 psi initial pressure. When the hydrogenation was complete, the solids were filtered off and the ethyl acetate was evaporated. The resulting diamine intermediate was heated with methoxyacetic acid (70 mL) at 150° C. for 2-3 hours and then at 120° C. for 2-3 hours. The reaction mixture was poured into water (400 mL), made strongly basic with 6N sodium hydroxide and then extracted with ether (3×200 mL). The ether extracts were combined, washed with brine then evaporated to provide 9.9 g of an oil which crystallized on standing. The aqueous layers were extracted again with ether (4×200 mL). The extracts were combined, washed with brine and evaporated. The residue was recrystallized from ethyl acetate to provide 1.5 g yellow needles. Analysis: Calculated: C, 66.4; H, 6.3; N, 15.5; Found: C, 66.6; H, 6.4; N, 16.1.
Workup
- filtrationthe solids were filtered off
- customthe ethyl acetate was evaporated
- additionThe reaction mixture was poured into water (400 mL)
- extractionextracted with ether (3×200 mL)
- washwashed with brine
- customthen evaporated
Sources & evidence
- ORD record
- ord-859bb98fdaa448c3b215b058c875071f
- Source dataset
- uspto-grants-2002_10
- Patent number
- US06465654B2
Reaction notes
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