1-Adamantanecarbonyl chloride → N-phenyl-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide

HRID 992312Notes

Reaction equation

HRID 992312 reaction equation
[NH:1]([CH:8]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:22]12([C:32](Cl)=[O:33])[CH2:31][CH:26]3[CH2:27][CH:28]([CH2:30][CH:24]([CH2:25]3)[CH2:23]1)[CH2:29]2>>[C:2]1([N:1]([CH:8]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][C:15]3[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=3)[CH2:9]2)[C:32]([C:22]23[CH2:31][CH:26]4[CH2:25][CH:24]([CH2:30][CH:28]([CH2:27]4)[CH2:29]2)[CH2:23]3)=[O:33])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 989151-Adamantanecarbonyl chlorideHCID 184119313-Anilino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 18411836N-phenyl-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide

Procedure

3-Anilino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine and 1-adamantanecarbonyl chloride were reacted under the same conditions as in Example 53 to give N-phenyl-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide.

Sources & evidence

ORD record
ord-314477ff033d42159d5787b3f5fe0f5e
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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