Dimethylformamide → Tert-butyl 2-(3-((7-methoxyquinolin-4-yloxy)methyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamido)ethyl(methyl)carbamate

HRID 99261Notes

Reaction equation

HRID 99261 reaction equation
[C:27]([CH3:28])([CH3:29])([CH3:30])[O:31][C:32]([N:33]([CH3:34])[CH2:35][CH2:36][NH2:37])=[O:38].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([O:13][CH2:14][c:15]3[n:16][n:17][c:18]4[n:19]3[cH:20][c:21]([C:24](=[O:25])[OH:26])[cH:22][cH:23]4)[cH:8][cH:9][n:10][c:11]2[cH:12]1.[CH3:63][CH2:64][N:65]([CH2:66][CH3:67])[CH2:68][CH3:69].[F:39][P-:40]([F:41])([F:42])([F:43])([F:44])[F:45].[O:70]=[CH:71][N:72]([CH3:73])[CH3:74].[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[n:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([O:13][CH2:14][c:15]3[n:16][n:17][c:18]4[n:19]3[cH:20][c:21]([C:24](=[O:25])[NH:37][CH2:36][CH2:35][N:33]([C:32]([O:31][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:38])[CH3:34])[cH:22][cH:23]4)[cH:8][cH:9][n:10][c:11]2[cH:12]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 2756424N-Boc-N-methylethylenediamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 576912183-((7-Methoxyquinolin-4-yloxy)methyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid

Product 1

HCID 57691109Tert-butyl 2-(3-((7-methoxyquinolin-4-yloxy)methyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamido)ethyl(methyl)carbamate

Sources & evidence

ORD record
ord-b7c49f0df18d47488e23ccb553c3c46a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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