4-(2-Trifluoromethylphenyl)-3-buten-2-one → 4-[2-(Trifluoromethyl)phenyl]butan-2-one

HRID 9928Notes

Reaction equation

HRID 9928 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]=[CH:10][C:11](=[O:13])[CH3:12]>[Ni].C(OCC)(=O)C>[F:1][C:2]([F:14])([F:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11](=[O:13])[CH3:12]

Participants

4

Reactant 1

HCID 5226124-(2-Trifluoromethylphenyl)-3-buten-2-one

Product 1

HCID 117460214-[2-(Trifluoromethyl)phenyl]butan-2-one

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8857Ethyl AcetateSolvent

Procedure

200 mg of Raney nickel are added to a solution of 2.05 g of 4-(2-trifluoromethylphenyl)-3-buten-2-one in 100 ml of ethyl acetate and the mixture is stirred under a hydrogen atmosphere and at standard pressure for 7 h. The mixture is subsequently filtered and the filtrate is evaporated under reduced pressure, whereby the title compound is obtained.

Workup

  1. filtrationThe mixture is subsequently filtered
  2. customthe filtrate is evaporated under reduced pressure, whereby the title compound
  3. customis obtained

Sources & evidence

ORD record
ord-456684d1f9d94974b8fd4c859ea625b7
Source dataset
uspto-grants-2006_08
Patent number
US07091371B2

Reaction notes

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