反应详情

4-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)thiazole (1.53 g) was dissolved in a mixed solvent of DMSO (5 mL) and triethylamine (2.3 mL), and sulfur trioxide pyridine complex (98%, 3.09 g) was added portionwise to the solution at room temperature. After 1 hour, the reaction mixture was diluted with ethyl acetate, washed with water and saturated brine and dried over anhydrous sodium sulfate. After concentrating the reaction mixture under reduced pressure, the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1 to 1:2) to obtain the title compound.

1. additionwas added portionwise to the solution at room temperature
2. washwashed with water and saturated brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationAfter concentrating the reaction mixture under reduced pressure
5. customthe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1 to 1:2)