Hydrochloric Acid → HCID 178487477, compound

HRID 993019Notes

Reaction equation

HRID 993019 reaction equation
COC[N:4]1[C:8]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)=[CH:7][C:6]([CH2:21][N:22]2[CH2:27][CH2:26][N:25]([CH2:28][C:29]3[CH:33]=[C:32]([C:34]4[CH:39]=[C:38]([O:40][CH3:41])[C:37]([O:42][CH3:43])=[C:36]([O:44][CH3:45])[CH:35]=4)[N:31](COC)[N:30]=3)[CH2:24][CH2:23]2)=[N:5]1.C(OCC)(=O)C.[ClH:55]>C(Cl)(Cl)Cl>[ClH:55].[ClH:55].[CH3:45][O:44][C:36]1[CH:35]=[C:34]([C:32]2[NH:31][N:30]=[C:29]([CH2:28][N:25]3[CH2:24][CH2:23][N:22]([CH2:21][C:6]4[CH:7]=[C:8]([C:9]5[CH:10]=[C:11]([O:19][CH3:20])[C:12]([O:17][CH3:18])=[C:13]([O:15][CH3:16])[CH:14]=5)[NH:4][N:5]=4)[CH2:27][CH2:26]3)[CH:33]=2)[CH:39]=[C:38]([O:40][CH3:41])[C:37]=1[O:42][CH3:43]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 18408484HCID 18408484, compound

Product 1

HCID 178487477HCID 178487477, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

N,N′-Bis[[1-methoxymethyl-5-(3,4,5-trimethoxy-phenyl)pyrazol-3-yl]methyl]piperazine (71 mg) was dissolved in chloroform (3 mL), and to the solution an ethyl acetate solution (0.7 mL) of 4 M hydrochloric acid was added at room temperature, and the mixture was stirred for 3 hours. After concentrating the reaction mixture, the residue was sufficiently dried and recrystallized from methanol-diisopropyl ether to obtain the title compound.

Workup

  1. concentrationAfter concentrating the reaction mixture
  2. customthe residue was sufficiently dried
  3. customrecrystallized from methanol-diisopropyl ether

Sources & evidence

ORD record
ord-ba1a9fc7bbef4252a47c6278fb670ac6
Source dataset
uspto-grants-2002_10
Patent number
US06472386B1

Reaction notes

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