Hydrogen Bromide → HCID 18408835, compound

HRID 993049Notes

Reaction equation

HRID 993049 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:14](=[O:15])[NH:13][C:12](=[O:16])[NH:11][C:10]2=[O:17])=[CH:5][CH:4]=1.[BrH:18].BrBr>O>[Br:18][C:9]1([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[C:10](=[O:17])[NH:11][C:12](=[O:16])[NH:13][C:14]1=[O:15]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 18408750HCID 18408750, compound

Product 1

HCID 18408835HCID 18408835, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
2.5 °C

Procedure

To a suspension of 5-(4-Methoxyphenyl)barbituric acid (222 mg) in 3 ml of water, cooled to 0-5° C. with ice bath, are added 136 μl of 48% hydrobromic acid and 56 μl of bromine, dropwise. After 1 hour at a temperature below 10° C., the solid which separated is collected by filtration and washed on the filter with water. The solid is dried for several hours under vacuum at 50° C., to give 283 mg of the product.

Workup

  1. customthe solid which separated
  2. filtrationis collected by filtration
  3. washwashed on the
  4. filtrationfilter with water
  5. customThe solid is dried for several hours under vacuum at 50° C.

Sources & evidence

ORD record
ord-2665cb084cde4d90af098c366a82a8bb
Source dataset
uspto-grants-2002_10
Patent number
US06472396B1

Reaction notes

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