反应详情

To a solution of sodium (184 mg) in 12 ml of ethanol are added 0.95 ml of diethyl 2-(4-Methylphenyl)malonate and 360 mg of urea, then the mixture is refluxed for 3 hours. A white solid separates, which is filtered and redissolved in 4 ml of water. The solution is acidified to pH=1-2 by adding 6 N hydrochloric acid. A white solid separates, which is collected by filtration, washed with 15 ml of water and dried under vacuum. 619 mg of the product are obtained, m.p. 271° C.

1. temperaturethe mixture is refluxed for 3 hours
2. filtrationA white solid separates, which is filtered
3. dissolutionredissolved in 4 ml of water
4. additionby adding 6 N hydrochloric acid
5. filtrationA white solid separates, which is collected by filtration
6. washwashed with 15 ml of water
7. customdried under vacuum