Hydrogen Bromide → 5-Bromo-5-(4-methylphenyl)barbituric acid

HRID 993069Notes

Reaction equation

HRID 993069 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10][C:9]2=[O:16])=[CH:4][CH:3]=1.[BrH:17]>O>[Br:17][C:8]1([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=2)[C:9](=[O:16])[NH:10][C:11](=[O:15])[NH:12][C:13]1=[O:14]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 45769115-(4-methylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Product 1

HCID 184086585-Bromo-5-(4-methylphenyl)barbituric acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 5-(4-Methylphenyl)barbituric Acid (218 mg) in 2 ml of water, kept at 10° C. under stirring, 136 μl of 48% hydrobromic acid are added then 56 μl of brominr are dropped and the stirring is continued for 3 hours. The precipitate which formed is recovered by filtration and washed with water, then it is dried under vacuum to give 270 mg of the product, m.p. 210-213° C.

Workup

  1. customkept at 10° C.
  2. addition56 μl of brominr are dropped
  3. customThe precipitate which formed
  4. filtrationis recovered by filtration
  5. washwashed with water
  6. customit is dried under vacuum

Sources & evidence

ORD record
ord-8aed7178812646fea7ef307633128094
Source dataset
uspto-grants-2002_10
Patent number
US06472396B1

Reaction notes

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