Urea → HCID 18408739, compound

HRID 993083Notes

Reaction equation

HRID 993083 reaction equation
[CH2:1]([CH:11]([C:17]([O:19]CC)=O)[C:12]([O:14]CC)=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[O-]CC.[Na+].[NH2:26][C:27]([NH2:29])=[O:28]>C(O)C>[CH2:1]([CH:11]1[C:12](=[O:14])[NH:29][C:27](=[O:28])[NH:26][C:17]1=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 1176UreaHCID 252345Diethyl DecylmalonateHCID 2723922Sodium ethoxide

Product 1

HCID 18408739HCID 18408739, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of diethyl decylmalonate of step a) in 40 ml of ethanol are added 2.72 g of sodium ethoxide and then 1.8 g of urea. The reaction mixture is refluxed for 2 hours, then the precipitate is filtered and redissolved in 40 ml of water. The resulting aqueous solution is acidified with 6 N hydrochloric acid. The solid which separates is recovered by filtration and dried under vacuum at 40° C. overnight, to give 2.152 g of the product, m.p. 190° C.

Workup

  1. temperatureThe reaction mixture is refluxed for 2 hours
  2. filtrationthe precipitate is filtered
  3. dissolutionredissolved in 40 ml of water
  4. filtrationThe solid which separates is recovered by filtration
  5. customdried under vacuum at 40° C. overnight

Sources & evidence

ORD record
ord-cfe479e7ef824c36a5e2ba0f9993d852
Source dataset
uspto-grants-2002_10
Patent number
US06472396B1

Reaction notes

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