HCID 70128057, compound → HCID 10181214, compound

HRID 993237Notes

Reaction equation

HRID 993237 reaction equation
C([O:5][C:6](=[O:35])[CH2:7][C@@H:8]([C:27]1[CH:28]=[N:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=1)[N:9]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][C:17](=[O:25])[NH:18][C:19]2[NH:20][CH2:21][CH2:22][CH2:23][N:24]=2)[C:10]1=[O:26])(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[CH3:34][O:33][C:30]1[N:29]=[CH:28][C:27]([C@@H:8]([N:9]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][C:17](=[O:25])[NH:18][C:19]3[NH:20][CH2:21][CH2:22][CH2:23][N:24]=3)[C:10]2=[O:26])[CH2:7][C:6]([OH:35])=[O:5])=[CH:32][CH:31]=1

Participants

4

Reactant 1

HCID 70128057HCID 70128057, compound

Product 1

HCID 10181214HCID 10181214, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the ester 1-9(110 mg) in dichloromethane (10 mL) and trifluoroacetic acid (10 mL) were stirred at room temperature for 2 hours. The mixture was concentrated in vacuo, dissolved in water, frozen and lyophilized to give 1-10as a powder.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutiondissolved in water
  3. temperaturefrozen
  4. customto give 1-10as a powder

Sources & evidence

ORD record
ord-2b9be4888e434efdbe7db290cbbbbe29
Source dataset
uspto-grants-2002_10
Patent number
US06472403B2

Reaction notes

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