反应详情

A solution of 4-bromo-2,6-dichlorophenol (1.24 g, 6.02 mmol), methyl (2S)-2-hydroxy-3-phenylpropanoate (1.30 g, 7.22 mmol) and triphenylphosphine (2.05 g, 7.83 mmol) in THF (13 mL) at room temperature was treated with DEAD (1.28 mL, 8.13 mmol), stirred for 2 hours, and concentrated. The concentrate was triturated with 10% ethyl acetate/hexanes, filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5% ethyl acetate/hexanes to provide 1.90 g (78%) of the desired product.

1. concentrationconcentrated
2. customThe concentrate was triturated with 10% ethyl acetate/hexanes
3. filtrationfiltered
4. concentrationconcentrated
5. customThe concentrate was purified by flash column chromatography on silica gel with 5% ethyl acetate/hexanes