1,2-Dichloroethane → 4-[4-(2,5,7-Trimethyl-3H-imidazo[4,5-b]pyridin-3-ylmethyl)phenylamino]methyl-1-(4-tetrahydropyranyl)piperidine

HRID 99876Notes

Reaction equation

HRID 99876 reaction equation
[C:35]([O:36][BH-:37]([O:38][C:39](=[O:40])[CH3:41])[O:42][C:43](=[O:44])[CH3:45])(=[O:46])[CH3:47].[CH3:1][c:2]1[n:3][c:4]2[c:5]([n:6][c:7]([CH3:11])[cH:8][c:9]2[CH3:10])[n:12]1[CH2:13][c:14]1[cH:15][cH:16][c:17]([NH:20][CH2:21][CH:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[cH:18][cH:19]1.[Cl:51][CH2:52][CH2:53][Cl:54].[Na+:48].[Na+:50].[O:28]1[CH2:29][CH2:30][C:31](=[O:34])[CH2:32][CH2:33]1.[OH-:49]>>[CH3:1][c:2]1[n:3][c:4]2[c:5]([n:6][c:7]([CH3:11])[cH:8][c:9]2[CH3:10])[n:12]1[CH2:13][c:14]1[cH:15][cH:16][c:17]([NH:20][CH2:21][CH:22]2[CH2:23][CH2:24][N:25]([CH:31]3[CH2:30][CH2:29][O:28][CH2:33][CH2:32]3)[CH2:26][CH2:27]2)[cH:18][cH:19]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 923Sodium ion2×HCID 961HydroxideHCID 121599Tetrahydro-4H-pyran-4-oneHCID 2724942TriacetoxyborohydrideHCID 23156137HCID 23156137, compound

Product 1

HCID 694376334-[4-(2,5,7-Trimethyl-3H-imidazo[4,5-b]pyridin-3-ylmethyl)phenylamino]methyl-1-(4-tetrahydropyranyl)piperidine

Sources & evidence

ORD record
ord-8c9091dd5e2e47bbbb9e5614477e6c3e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…