膦胺霉素 → 膦胺霉素

HRID 1706224

反应方程式

HRID 1706224 反应方程式
[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[Al+3:11].[K+].[Na].[CH:14]([N:16]([CH2:18][CH2:19][CH2:20][P:21](=[O:24])([OH:23])[OH:22])[OH:17])=[O:15].[OH-].[Na+]>>[Al:11].[CH:14]([N:16]([CH2:18][CH2:19][CH2:20][P:21](=[O:22])([OH:24])[OH:23])[OH:17])=[O:15]

参与物

6

反应物 4

HCID 572膦胺霉素HCID 14798二甲基对苯二胺二盐酸HCID 24856Potassium AlumHCID 5360545钠

产物 2

HCID 572膦胺霉素收率 74%HCID 5359268铝

实验过程

To an aqueous solution (45 ml.) of potassium alum (9.17 g.) was added mono sodium salt of 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (3.08 g.) with stirring, and the solution was adjusted to pH 6-7 with 10% aqueous sodium hydroxide solution and then stirred for 2 hours at ambient temperature. The precipitating materials were collected by filtration, washed twice with water (each 10 ml.) and dried to give aluminum salt of 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (2.28 g.).

后处理

  1. stirringstirred for 2 hours at ambient temperature
  2. filtrationThe precipitating materials were collected by filtration
  3. washwashed twice with water (each 10 ml
  4. custom) and dried

来源与证据

ORD记录
ord-b587d404e39a46bf913f82d39f50caeb
来源数据集
uspto-grants-1980_06
专利号
US04206156

关联笔记

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