盐酸羟胺 → HCID 178492604，化合物
反应方程式
C([O-])(=O)C.[Na+].[CH3:6][O:7][C:8]1[CH:17]=[CH:16][C:11]([O:12][CH2:13][C:14]#[N:15])=[CH:10][CH:9]=1.Cl.[NH2:19][OH:20]>CO>[OH:20][NH:19][C:14](=[NH:15])[CH2:13][O:12][C:11]1[CH:16]=[CH:17][C:8]([O:7][CH3:6])=[CH:9][CH:10]=1参与物
5
实验过程
Add sodium acetate (5.1 g, 62 mmol) to 4-methoxyphenoxyacetonitrile (5.0 g, 31 mmol) and hydroxylamine hydrochloride (4.3 g, 62 mmol) in methanol (100 mL). Stir the resulting mixture at room temperature for 20 hours. Filter the resulting mixture through Celite, concentrate, stir in chloroform for 18 hours and filter. Concentrate the resulting solution to the title compound (5.1 g). LC-MS (m/e): 197 (M+1).
后处理
- filtrationFilter the resulting mixture through Celite
- concentrationconcentrate
- stirringstir in chloroform for 18 hours
- filtrationfilter
- concentrationConcentrate the resulting solution to the title compound (5.1 g)
来源与证据
- ORD记录
- ord-d39ad66f202246dd8dafd3dd29238ba0
- 来源数据集
- uspto-grants-2010_09
- 专利号
- US07803938B2
反应笔记
加载中…